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the pad U4500-D2 is missing can i run a jumper from C1 to make is work

Yes, you can. You can also connect it to any ground point. Small micro-jumpers that are totally beneath the IC can be hard to work with because once you solder the IC in place, you have no way of knowing if the jumper stayed in place. With a jumper leaving the IC, you at least control one side of the jumper. It’s always preferable to us UV-curable mask to hold the jumper in place.