Chosen Solution

I have a Nvidia card in my 2008 MacPro and want to install a Nvidia 650M graphic card for playing Call of Duty and other games. My current system is Mountain Lion

Remove the screw holding the card in place on the bracket holding it in place. Push the tab on the lower back bottom of the card to release the AGP tab and lift the card up. Here’s the guide for doing it: PCI Express Cards (Early 2008)